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Editor's Notes

• #5: ��cancer-specific survival (CSS
• #14: In patients unfit for surgery, SABR is the treatment of choice for peripherally located stage I NSCLC (if SABR is not available, a hypofractionated radiotherapy schedule with a high biologically equivalent dose is advised) [III, A]. SABR has led to improved population-based survival in elderly patients [34], and the convenience of this outpatient therapy over three to eight visits has also led to a reduction in the proportion of untreted patients. The SABR dose should be to a biologically equivalent tumour dose of ≥100 Gy, prescribed to the encompassing isodose. A systematic review comparing outcomes of SABR and surgery in patients with severe COPD revealed a higher 30-day mortality following surgery but similar OS at 1 and 3 years [35]. Analysis of SABR outcomes in 676 patients found a median OS of 40.7 months, and actuarial 5-year rates of initial local, regional and distant recurrence of 10.5%, 12.7% and 19.9%, respectively [36]. A systematic review of SABR in centrally located tumours found local control rates of >85% with biologically equivalent doses ≥100 Gy [37]. The risk of highgrade toxic effect was <9% when the biologically equivalent normal tissue dose was ≤210 Gy. Prospective trials of SABR versus primary resection are now underway. For tumours with a size >5 cm and/or central location, far less data are available for SABR. These patients are preferentially treated with radical radiotherapy using more conventional daily or accelerated schedules [38] [III, A]. Adding chemotherapy to radiotherapy for patients with stage II-N1 disease may be considered [V, C]. Although
• #36: The North American��Intergroup 0139��trial
• #41: In selected patients with pathologically proven stage IIIA-N2 NSCLC and a response to induction chemotherapy, surgical resection did not improve overall or progression-free survival compared with radiotherapy. In view of its low morbidity and mortality, radiotherapy should be considered the preferred locoregional treatment for these patients.
• #50: 6 ΜΕΛΕΤΕΣ
• #70: Results: 464 pts were accrued prior to closure of the HD arm in 6/11, of which 419 were eligible for analysis. Median follow up was 17.2 months. There were 2 and 10 grade 5 treatment-related adverse events(AEs) on the SD and HD arms, respectively. Grade 3+AEs were 74.2% and 78.2% on SD and HD arms, respectively (p=0.34). The median survival times and 18-month OS rates for the SD and HD arms were 28.7 vs 19.5 months, and 66.9% vs 53.9% respectively (p=0.0007). The primary cause of death was lung cancer (72.2% vs 73.5%)(p=0.84). Local failure rates at 18 months were 25.1% vs 34.3% for SD and HD patients, respectively(p=0.03). Local-regional and distant failures at 18 months were 35.3% vs 44%(p=0.04) and 42.4% vs 47.8%(p=0.16) for SD and HD arms, respectively. Factors predictive of less favorable OS on multivariate analysis were higher radiation dose, higher esophagitis/dysphagia grade, greater gross tumor volume, and heart volume >5 Gy. Conclusions: In this setting of chemoradiation for locally-advanced Stage III NSCLC, 60 Gy is superior to 74 Gy in terms of OS and local-regional control. The effect of the anti-EGFR antibody (cetuximab) awaits further follow up
• #72: elective