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CRISPR is a new gene-editing technique that allows DNA to be precisely cut and replaced. Scientists are debating the ethics of using it to edit human embryos or genes that could be inherited by future generations. While CRISPR has potential medical benefits, its ability to "choose characteristics of future human generations" is controversial.
The document discusses the history and development of gene editing technology, including how CRISPR/Cas9 has allowed for quick and efficient genetic modification in human cells and animal models. While gene editing holds promise for understanding disease and potentially treating genetic conditions, its use in human embryos particularly with CRISPR/Cas9 raises significant ethical concerns about human germline modification and eugenics. The document argues that prominent scientists have rightly begun discussions around the ethical implications of modifying the human genome.
This document discusses genetic engineering and gene editing technologies like CRISPR-Cas9. It explores both the promise and ethical concerns of being able to directly alter genes. While gene editing could help address diseases and boost agriculture, there are risks of unintended consequences due to off-target mutations or unknown long term effects of disrupting the natural human genome. The document examines arguments on both sides and notes that while scientific research is important, manipulating human heredity remains an issue of ethics that requires careful consideration and debate.
(1) CRISPR-Cas9 is a new genetic editing technique that allows easier correction of faulty genes. It has potential for treating genetic diseases but also raises ethical concerns.
(2) The document discusses using CRISPR-Cas9 to edit somatic/adult cells (acceptable) vs germline/embryonic cells (controversial). Editing germline cells could affect future generations and paves the way for "designer babies".
(3) The proposed position is to continue CRISPR-Cas9 research on animals and adult cells but support a moratorium on human germline/embryonic editing and a permanent ban due to safety issues and concerns about human
CRISPR Cas9 is a genome editing technique that uses the Cas9 enzyme to cut DNA at specific locations. In 2018, Dr. He Jiankui conducted the first human genome editing trial using CRISPR Cas9 to modify embryos' genes in an attempt to make them resistant to HIV. This resulted in the birth of twin girls known as "Nana" and "Lulu". However, Dr. He's experiment was highly controversial and considered unethical due to safety risks. While genome editing holds promise for treating disease, more research is needed to address ethical concerns before making heritable genetic changes.
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This document provides an overview of rhetoric and argument essays. It discusses the essential elements of an argument, including the claim, evidence, counterargument, and rebuttal. It notes that a successful argument depends on balancing these elements. The document then outlines the typical sections of an argument essay, including an introduction with a thesis, presenting the position agreed with and supported by evidence, presenting the opposing position and circumstances where it could be valid, rebutting the opposition's stance, and providing a conclusion. It also briefly introduces the concept of a consensual or Rogerian argument.
The applicant wishes to attend the University of Michigan's School of Literature, Science, and the Arts due to its reputation and success over many decades. They have dreamed of becoming a Michigan Wolverine and studying biology and psychology. The school offers a wide range of majors and programs, as well as the opportunity to transfer to higher-level institutes. The applicant believes the school's comprehensive studies program and over 3,000 classes per semester will help ensure their future career success.
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The document discusses the development of one's sense of self. It explains that our interactions with others from a young age shape how we see ourselves and how we act around others. The "looking glass self" theory proposes that we see our self through the way we believe others perceive us based on their reactions. This leads us to develop either positive or negative self-concepts. Our sense of self continues changing throughout life as our environments and experiences change.
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Soil erosion from farms can have negative environmental impacts by reducing nutrient-rich topsoil, increasing sedimentation in waterways which harms aquatic ecosystems, and allowing chemicals from fertilizers and pesticides to pollute drinking water sources as they run off from fields. Prevention methods for farms include maintaining ground cover through no-till practices and buffer zones, while damage control involves restoring eroded lands and setting limits on chemical usage to protect water quality.
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The document provides background information on Plato and discusses his work The Republic. It notes that Plato was born in Athens to a politically connected family. Events like the Peloponnesian War and execution of his mentor Socrates altered Plato's life path away from politics. The summary discusses how The Republic explores the concept of justice and how it exists in different forms. It argues that Plato believes justice is an intrinsic virtue that is necessary for achieving a good life and that his work is neither purely deontological nor consequentialist in nature.
High school and college have different levels of education but both aim to further students' knowledge. Some similarities are that they both have classrooms, assignments, and students. However, there are three main differences - teachers, classes, and responsibilities. In high school, teachers provide more structured lessons while professors typically focus on tests and papers. Class sizes are smaller in high school than college. Additionally, high school has more structured time and responsibility while college requires more independent time management and responsibility over one's schedule and studies.
Physics plays an important role in soccer. Kinetic and potential energy allow players to kick the ball with force and accuracy. The physics of projectile motion determines how far and where the ball will go when kicked. Friction between shoes and the ground enables players to change direction quickly and stop or start with precision. Understanding physics can help soccer players improve their skills and performance.
Cognitive development refers to gradual changes in mental processes that make thinking more complex and sophisticated over time. Jean Piaget studied cognitive development extensively and identified four stages through which children progress: sensorimotor, preoperational, concrete operational, and formal operational. The preoperational stage from ages 2-7 is characterized by the emergence of symbolic thought and imagination, though children are still egocentric and unable to take others' perspectives.
APM event hosted by the South Wales and West of England Network (SWWE Network)
Speaker: Aalok Sonawala
The SWWE Regional Network were very pleased to welcome Aalok Sonawala, Head of PMO, National Programmes, Rider Levett Bucknall on 26 February, to BAWA for our first face to face event of 2025. Aalok is a member of APMs Thames Valley Regional Network and also speaks to members of APMs PMO Interest Network, which aims to facilitate collaboration and learning, offer unbiased advice and guidance.
Tonight, Aalok planned to discuss the importance of a PMO within project-based organisations, the different types of PMO and their key elements, PMO governance and centres of excellence.
PMOs within an organisation can be centralised, hub and spoke with a central PMO with satellite PMOs globally, or embedded within projects. The appropriate structure will be determined by the specific business needs of the organisation. The PMO sits above PM delivery and the supply chain delivery teams.
For further information about the event please click here.
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This document provides an overview of rhetoric and argument essays. It discusses the essential elements of an argument, including the claim, evidence, counterargument, and rebuttal. It notes that a successful argument depends on balancing these elements. The document then outlines the typical sections of an argument essay, including an introduction with a thesis, presenting the position agreed with and supported by evidence, presenting the opposing position and circumstances where it could be valid, rebutting the opposition's stance, and providing a conclusion. It also briefly introduces the concept of a consensual or Rogerian argument.
The applicant wishes to attend the University of Michigan's School of Literature, Science, and the Arts due to its reputation and success over many decades. They have dreamed of becoming a Michigan Wolverine and studying biology and psychology. The school offers a wide range of majors and programs, as well as the opportunity to transfer to higher-level institutes. The applicant believes the school's comprehensive studies program and over 3,000 classes per semester will help ensure their future career success.
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The document is a personal reflection on the film "Touching the Void" about overcoming adversity. The key points made are:
- The film taught about the true meaning of adversity as any time of great misfortune, large or small.
- The biggest message was that persevering and not giving up allows one to overcome adversity through coping strategies.
- An example showed how being better prepared may have led to a better outcome when facing challenges or tests.
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The document discusses the development of one's sense of self. It explains that our interactions with others from a young age shape how we see ourselves and how we act around others. The "looking glass self" theory proposes that we see our self through the way we believe others perceive us based on their reactions. This leads us to develop either positive or negative self-concepts. Our sense of self continues changing throughout life as our environments and experiences change.
Louis XIV Essay examples
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Soil erosion from farms can have negative environmental impacts by reducing nutrient-rich topsoil, increasing sedimentation in waterways which harms aquatic ecosystems, and allowing chemicals from fertilizers and pesticides to pollute drinking water sources as they run off from fields. Prevention methods for farms include maintaining ground cover through no-till practices and buffer zones, while damage control involves restoring eroded lands and setting limits on chemical usage to protect water quality.
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The document provides background information on Plato and discusses his work The Republic. It notes that Plato was born in Athens to a politically connected family. Events like the Peloponnesian War and execution of his mentor Socrates altered Plato's life path away from politics. The summary discusses how The Republic explores the concept of justice and how it exists in different forms. It argues that Plato believes justice is an intrinsic virtue that is necessary for achieving a good life and that his work is neither purely deontological nor consequentialist in nature.
High school and college have different levels of education but both aim to further students' knowledge. Some similarities are that they both have classrooms, assignments, and students. However, there are three main differences - teachers, classes, and responsibilities. In high school, teachers provide more structured lessons while professors typically focus on tests and papers. Class sizes are smaller in high school than college. Additionally, high school has more structured time and responsibility while college requires more independent time management and responsibility over one's schedule and studies.
Physics plays an important role in soccer. Kinetic and potential energy allow players to kick the ball with force and accuracy. The physics of projectile motion determines how far and where the ball will go when kicked. Friction between shoes and the ground enables players to change direction quickly and stop or start with precision. Understanding physics can help soccer players improve their skills and performance.
Cognitive development refers to gradual changes in mental processes that make thinking more complex and sophisticated over time. Jean Piaget studied cognitive development extensively and identified four stages through which children progress: sensorimotor, preoperational, concrete operational, and formal operational. The preoperational stage from ages 2-7 is characterized by the emergence of symbolic thought and imagination, though children are still egocentric and unable to take others' perspectives.
APM event hosted by the South Wales and West of England Network (SWWE Network)
Speaker: Aalok Sonawala
The SWWE Regional Network were very pleased to welcome Aalok Sonawala, Head of PMO, National Programmes, Rider Levett Bucknall on 26 February, to BAWA for our first face to face event of 2025. Aalok is a member of APMs Thames Valley Regional Network and also speaks to members of APMs PMO Interest Network, which aims to facilitate collaboration and learning, offer unbiased advice and guidance.
Tonight, Aalok planned to discuss the importance of a PMO within project-based organisations, the different types of PMO and their key elements, PMO governance and centres of excellence.
PMOs within an organisation can be centralised, hub and spoke with a central PMO with satellite PMOs globally, or embedded within projects. The appropriate structure will be determined by the specific business needs of the organisation. The PMO sits above PM delivery and the supply chain delivery teams.
For further information about the event please click here.
Digital Tools with AI for e-Content Development.pptxDr. Sarita Anand
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This ppt is useful for not only for B.Ed., M.Ed., M.A. (Education) or any other PG level students or Ph.D. scholars but also for the school, college and university teachers who are interested to prepare an e-content with AI for their students and others.
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In this slide, well discuss on how to modify existing web pages in Odoo 18. Web pages in Odoo 18 can also gather user data through user-friendly forms, encourage interaction through engaging features.
How to attach file using upload button Odoo 18Celine George
油
In this slide, well discuss on how to attach file using upload button Odoo 18. Odoo features a dedicated model, 'ir.attachments,' designed for storing attachments submitted by end users. We can see the process of utilizing the 'ir.attachments' model to enable file uploads through web forms in this slide.
QuickBooks Desktop to QuickBooks Online How to Make the MoveTechSoup
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If you use QuickBooks Desktop and are stressing about moving to QuickBooks Online, in this webinar, get your questions answered and learn tips and tricks to make the process easier for you.
Key Questions:
* When is the best time to make the shift to QuickBooks Online?
* Will my current version of QuickBooks Desktop stop working?
* I have a really old version of QuickBooks. What should I do?
* I run my payroll in QuickBooks Desktop now. How is that affected?
*Does it bring over all my historical data? Are there things that don't come over?
* What are the main differences between QuickBooks Desktop and QuickBooks Online?
* And more
How to use Init Hooks in Odoo 18 - Odoo 際際滷sCeline George
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In this slide, well discuss on how to use Init Hooks in Odoo 18. In Odoo, Init Hooks are essential functions specified as strings in the __init__ file of a module.
Blind Spots in AI and Formulation Science Knowledge Pyramid (Updated Perspect...Ajaz Hussain
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This presentation delves into the systemic blind spots within pharmaceutical science and regulatory systems, emphasizing the significance of "inactive ingredients" and their influence on therapeutic equivalence. These blind spots, indicative of normalized systemic failures, go beyond mere chance occurrences and are ingrained deeply enough to compromise decision-making processes and erode trust.
Historical instances like the 1938 FD&C Act and the Generic Drug Scandals underscore how crisis-triggered reforms often fail to address the fundamental issues, perpetuating inefficiencies and hazards.
The narrative advocates a shift from reactive crisis management to proactive, adaptable systems prioritizing continuous enhancement. Key hurdles involve challenging outdated assumptions regarding bioavailability, inadequately funded research ventures, and the impact of vague language in regulatory frameworks.
The rise of large language models (LLMs) presents promising solutions, albeit with accompanying risks necessitating thorough validation and seamless integration.
Tackling these blind spots demands a holistic approach, embracing adaptive learning and a steadfast commitment to self-improvement. By nurturing curiosity, refining regulatory terminology, and judiciously harnessing new technologies, the pharmaceutical sector can progress towards better public health service delivery and ensure the safety, efficacy, and real-world impact of drug products.
Prelims of Kaun TALHA : a Travel, Architecture, Lifestyle, Heritage and Activism quiz, organized by Conquiztadors, the Quiz society of Sri Venkateswara College under their annual quizzing fest El Dorado 2025.
APM People Interest Network Conference 2025
-Autonomy, Teams and Tension: Projects under stress
-Tim Lyons
-The neurological levels of
team-working: Harmony and tensions
With a background in projects spanning more than 40 years, Tim Lyons specialised in the delivery of large, complex, multi-disciplinary programmes for clients including Crossrail, Network Rail, ExxonMobil, Siemens and in patent development. His first career was in broadcasting, where he designed and built commercial radio station studios in Manchester, Cardiff and Bristol, also working as a presenter and programme producer. Tim now writes and presents extensively on matters relating to the human and neurological aspects of projects, including communication, ethics and coaching. He holds a Masters degree in NLP, is an NLP Master Practitioner and International Coach. He is the Deputy Lead for APMs People Interest Network.
Session | The Neurological Levels of Team-working: Harmony and Tensions
Understanding how teams really work at conscious and unconscious levels is critical to a harmonious workplace. This session uncovers what those levels are, how to use them to detect and avoid tensions and how to smooth the management of change by checking you have considered all of them.
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Odoo, a versatile and integrated business management software, excels with its robust Point of Sale (POS) module. This guide delves into the intricacies of configuring restaurants in Odoo 17 POS, unlocking numerous possibilities for streamlined operations and enhanced customer experiences.
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In this slide, well discuss on how to configure flexible working schedule in Odoo 18 Employee module. In Odoo 18, the Employee module offers powerful tools to configure and manage flexible working schedules tailored to your organization's needs.
APM People Interest Network Conference 2025
- Autonomy, Teams and Tension
- Oliver Randall & David Bovis
- Own Your Autonomy
Oliver Randall
Consultant, Tribe365
Oliver is a career project professional since 2011 and started volunteering with APM in 2016 and has since chaired the People Interest Network and the North East Regional Network. Oliver has been consulting in culture, leadership and behaviours since 2019 and co-developed HPTM速an off the shelf high performance framework for teams and organisations and is currently working with SAS (Stellenbosch Academy for Sport) developing the culture, leadership and behaviours framework for future elite sportspeople whilst also holding down work as a project manager in the NHS at North Tees and Hartlepool Foundation Trust.
David Bovis
Consultant, Duxinaroe
A Leadership and Culture Change expert, David is the originator of BTFA and The Dux Model.
With a Masters in Applied Neuroscience from the Institute of Organisational Neuroscience, he is widely regarded as the Go-To expert in the field, recognised as an inspiring keynote speaker and change strategist.
He has an industrial engineering background, majoring in TPS / Lean. David worked his way up from his apprenticeship to earn his seat at the C-suite table. His career spans several industries, including Automotive, Aerospace, Defence, Space, Heavy Industries and Elec-Mech / polymer contract manufacture.
Published in Londons Evening Standard quarterly business supplement, James Caans Your business Magazine, Quality World, the Lean Management Journal and Cambridge Universities PMA, he works as comfortably with leaders from FTSE and Fortune 100 companies as he does owner-managers in SMEs. He is passionate about helping leaders understand the neurological root cause of a high-performance culture and sustainable change, in business.
Session | Own Your Autonomy The Importance of Autonomy in Project Management
#OwnYourAutonomy is aiming to be a global APM initiative to position everyone to take a more conscious role in their decision making process leading to increased outcomes for everyone and contribute to a world in which all projects succeed.
We want everyone to join the journey.
#OwnYourAutonomy is the culmination of 3 years of collaborative exploration within the Leadership Focus Group which is part of the APM People Interest Network. The work has been pulled together using the 5 HPTM速 Systems and the BTFA neuroscience leadership programme.
https://www.linkedin.com/showcase/apm-people-network/about/
1. Embryo Editing Outline
BODY
I.What is embryo editing?
A.In order to edit embryos, you need to use a tool.
1.(..)Researchers have been developing tools since 1975 and throughout time Jennifer Doudna have
developed a tool called the CRISPRCas9 (Clustered regularly interspaced short palindromic
repeats associated genes).
B.(...) Researchers can edit genes by ridding the faulty genes and replacing the lettering(coding) with
the CRISPRCas9.
1.CRISPRCas9 is also known as genetic scissors. (...) While using the CRISPRCas9 researchers
are basically cutting out the faulty mutation and correcting it.
2.Once you do the genetic screening you can proceed with the gene splitting and edit them
efficiently. Gene splitting is done outside of the body, or preimplantation,...show more content...
According to The Guardian Now we can edit the embryo successfully so why should we do it.
II.Pros when it comes to embryo editing
A.When we look into curing or even reducing the frequency of viruses using the tool could make a
huge impact on many lives.
1.US and the Korean team have given evidence basically saying that when you edit the genes with
faulty mutations, you might not be able to fix them all the way but you can fix them from 50% to
70%. (...)
2.The US and Korean team can wipe out the faulty mutations from the sperm or the egg the virus
might be gone forever.
B.There are thousands of viruses in the human body that can come from one faulty mutation. (...)
This is a complex process because again there are thousands of viruses. When you have faulty
genes the chances it will be passed on to your kids is right in the middle at 50%. (...)
C.With new tool parents could have their ideal or genetically enhanced children they may desire
1.The US and Korean team created 58 human embryos while using the CRISPRCas9 they were able
to repair faulty genes up to 70%. (...) According to Quartz.
According to
The Guardian
Show diagram
According to
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2. Gene Editing Ethics
The days of human embryonic gene editing are rapidly approaching with the development of the
editing tool CRISPR/Cas9 and are crucial tools for understanding the molecular pathway and gene
functions. Genome editing technologies can quickly and efficiently modify the genomes by
introducing or genetically correcting mutations either in human cells or animal models, also
advanced towards mammalian models and clinical trials in humans. In China, the genetic
modification of human embryos using CRISPR/Cas9 tools was achieved by the Huang laboratory in
2015 and they have introduces new ethical questions regarding human treatment. CRISPR/Cas9 is
one of the newest genomic technologies that has completely revolutionized the understanding of
disease...show more content...
While the interest and use of CRISPR/Cas9 has exploded since its discovery in 2012 and since then
has seen a rapid improvements, prominent scientists in the field have already initiated conversations
regarding the ethical implications that arise when modifying the human genome. Preventing genetic
diseases by human genetic engineering is inevitable. Opening the doors for genetic engineering of
human embryos could with time lead to manipulate genetics for desirable traits, raising the fear of
creating a eugenic driven human
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3. Genome Editing Essay
Introduction
Genome editing is a huge leap forward in science and medicine. Because of recent advances in
technology, the study of genes and induced 'point' mutations have led to the discovery and
advancement of methods previously used in order to mutate genes. The development of Clusters
of Regularly Interspaced Short Palindromic Repeats (CRISPRs) and CRISPR associated system 9
protein (Cas9) technology is a hugely significant leap forward as this is a tool that could potentially
be used for the research into and hopefully the treatment of a range of medical conditions that are
genetically related. Cystic fibrosis (Schwank, G. et al, 2013), haemophilia and sickle cell disease are
an example of some of the conditions that have the...show more content...
Once the complex was bound to the DNA, a cut would be made to eliminate and destroy the
invaders. 83% of archaeal genomes and 45% of bacterial genomes (Shabbir, M. et al, 2016) were
shown to be able to successfully utilize the CRISPR Cas9 system. These are very promising
statistics, so it is no wonder that there has been such an advancement in the past few years to bring
this technology to eukaryotic cells, mammalian cells and eventually human cells.
With the rate and volume that new experiments and experimental procedures are being tried and
tested, it can be expected that a Nobel Prize will soon be won for the discovery and advancement of
this potential lifesaving 'tool'. The category of Nobel Prize and who it potentially should be
awarded to are discussed later in this essay.
The Role of CRISPR/Cas9 as a Genome Editing Tool
There are three types of CRISPR systems. The Type II CRISPR system (where the interface is
mediated by a single large protein in conjunction with crRNA) is the simplest of the three and it is
this one that has been the basis for genome editing.
The Cas9 protein is an enzyme that effectively acts as a pair of molecular 'scissors', cutting
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4. Peer Editing Analysis
The peer editing is to correct your paper from person who is in the same age or level and write
their opinion about it. That can help you to have other view from someone's in your level. It was
my first editing experience. I learned about something new in writing skills, which is how to edit
other paper, and how to give them your opinion. Also, when I see other personpaper, it helps me to
think widely and gain more ideas about how to be a good writer also whom I can read my paper as
critic to it. Moreover, it helps me to think correctly to give right advice to other person. Editing
peer gives me chance to participate with classmate how she thought. Moreover, it was as a practice
to my grammar when I correct my partner paper. I edited two papers
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5. Peer Editing Reflection
For the college essay practice paper we peer edited, reread, sought instructor advice, and rewrote
our essays until we felt that our paper was worthy of being turned in. By the end of the process we
should have had a final draft which was almost completely different from our original copies. This
process, in my opinion, is extremely valuable to the course as it is vital in order for incoming
students to improve their writing abilities. Personally, the technique in the process which forced me
to realize my mistakes on a broader level, more than any other step, was the one foot reading to find
syntax errors and awkward diction which our brains skim over when simply rereading the essay. Peer
editing, while still helpful, didn't seem as useful
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