Sharina
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Sharina was born in 1998 in Harlem Hospital and lives in Harlem with her grandmother and two uncles as her mother lives elsewhere. She attends University of TECNOLIGIE for 6th grade and enjoys reading in her room. Her favorite place to visit is her mother's house for the chocolate chip cookies. In elementary school, Sharina won a spelling trophy from her favorite teacher Ms. Williams. Her future goal is to study economics at Oxford University.
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Most drugs are metabolised ,atleast to some extent , by both phases of metabolism.
Example: Metabolism of Aspirin
Acetyl Salicylic acid undergoes hydrolysis to salicylic acid ( metabolic transformation ), which is then conjugated with glycine to form Salicyluric acid ( Conjugation ).
In Phase-II the metabolites formed in Phase-II are converted to more polar and water soluble product by attaching polar and ionisable moiety such as
1.Glucuronic acid
2.Glycine
3.Glutamine
4.Glutathione conjugation
5.Acetylation
6.Methylation
7.Sulfate conjugation
8.Nucleoside and Nucleotide formation
9.Amino Acid Conjugation
10.Fatty Acid and Cholesterol Conjugation
Drug design is the process of creating new drugs by using knowledge of a biological target.
Drug design considers metabolism to optimize pharmaco kinects ( ADME: Absorption , Distribution , Metabolism , Excretion )
Cytochrome CYP450 enzyme in Drug Metabolism is vital in drug design to enhance efficacy , reduce toxicity and improve bioavailability.
Cytochrome P450 enzymes (CYPs) are a superfamily of heme -containing proteins found from bacteria to human.
Cytochrome P-450 activity in various organs like Liver,Lung ,Kidney , Intestine,Placenta
Adrenal and Skin and they shows the relative activity with repect to their organs in the process of drug metabolism.
Most important CYP450 enzymes are CYP1A2 , CYP2C9 , CYP2E1
,etc...
Toxic Effects of Drug Metabolism
Toxicity: Accumulation of Excess of medications in the Blood Stream.
Ariens (1948) and Mitchell and Horning (1984) deal with this topic.
Some examples of Metabolism-Linked Toxicity are
1.Acetaminophen (paracetmol)
2.Isoniazid ( TB drug)
3.Chloroform
4.Dapsone
5.Diazepam
6.Salicylate
7.Halothane (Anesthetic)
8.Tamoxifen (Breast Cancer drug )
9.Clozapine(Antipsychotic)
These drugs are differentiates with the TOXIC METABOLITE , TOXICITY OF METABOLITE.
References for this topic also mentioned at the end.Decision Tree-ID3,C4.5,CART,Regression Tree
Decision Tree-ID3,C4.5,CART,Regression TreeGlobal Academy of Technology
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Machine Learning
Decision Tree
Problems on Decision TreeThe Splitting of the Moon (Shaqq al-Qamar).pdf
The Splitting of the Moon (Shaqq al-Qamar).pdfMirza Gazanfar Ali Baig
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This article explores the miraculous event of the Splitting of the Moon (Shaqq al-Qamar) as recorded in Islamic scripture and tradition. Drawing from the Qur'an, authentic hadith collections, and classical tafsir, the article affirms the event as a literal miracle performed by Prophet Muhammad 鏃 in response to the Qurayshs demand for a sign. It also investigates external historical accounts, particularly the legend of Cheraman Perumal, a South Indian king who allegedly witnessed the miracle and embraced Islam. The article critically examines the authenticity and impact of such regional traditions, while also discussing the lack of parallel astronomical records and how scholars have interpreted this event across centuries. Concluding with the theological significance of the miracle, the article offers a well-rounded view of one of Islams most discussed supernatural events.Education Funding Equity in North Carolina: Looking Beyond Income
Education Funding Equity in North Carolina: Looking Beyond IncomeEducationNC
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From the Center for Racial Equity in Education, research affiliate Kris Nordstrom studies education funding equity across North Carolina.Low Vison introduction from Aligarh Muslim University
Low Vison introduction from Aligarh Muslim UniversityAligarh Muslim University, Aligarh, Uttar Pradesh, India
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YSPH VMOC Special Report - Measles Outbreak Southwest US 5-21-2025.pptx
YSPH VMOC Special Report - Measles Outbreak Southwest US 5-21-2025.pptxYale School of Public Health - The Virtual Medical Operations Center (VMOC)
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Sharina
- 1. THE DAYS OF MY LIFE SHARINA P ADRON
- 2. BIRTHPLACE I was born on March 10, 1998 in Harlem Hospital.
- 3. My Community I live in Harlem we have a lot of people and a lot of close friends they help me a lot . I like to play in the park.
- 4. My Family I live with My Grandma and my two uncles .My Mom live somewhere else so I cant see her a lot I Miss my dad a lot.
- 5. Schools My school I been to was P.S,36 when I was in second grade.the school I am attend is the university of TECNOLIGIE for 6 grade.
- 6. Hobbies My Favorite Hobbies are reading. I like to read in my room because I can concentrate.
- 7. My favorite we place to visit to go is to my mom house because she make the best Chocolate chip cookies and I love her for that because she is the best mother in the whole entire world. My favorite place to visit
- 8. achievements I won a spelling trophy in p.s.36.my teacher was Ms.WILLIAMS.she was my best teacher in school.she always would teach us right and not wrong she was very nice in my school.
- 9. FUTURE GOALS I want to go to Oxford University when I grow up I want to study Economics in things that I like to achieve.