Role of the pharmacist in medication safety.Subash321Role of the pharmacist in medication safety. In this you know about the medication safety, medication error & how to prevent medication error. And the role of the pharmacists in medication safety.
pharmacy prac in Ethiop.Mohammed MohammedThis document discusses the evolution of pharmacy education and practice in Ethiopia. It describes how the traditional curriculum focused more on products than patients, lacking clinical training. Reforms were implemented in 2008 to make the curriculum more patient-centered, with additional clinical pharmacy courses and master's programs. This shift was needed to address Ethiopia's disease burden and meet global pharmacy standards. The new curriculum focuses on applying drug therapy clinically and monitoring treatment. Pharmacists trained this way are now recognized members of healthcare teams. While challenges remain, future plans include training all pharmacists clinically and potentially launching a PharmD program.
Drug transport and drug targeting - rumana hameedRumana HameedThis document discusses genetic polymorphisms in drug transporters and drug targets. It covers various methods of targeted drug delivery including first, second, and third order targeting based on the specific cells or tissues targeted. Passive and active targeting approaches are described along with examples like magnetic drug targeting using nanoparticles, liposomes, transdermal patches, and brain-targeted delivery systems. The conclusion emphasizes that targeted drug delivery can reduce dose and side effects by assisting drugs to reach the desired site.
How ICT Enables Personalized MedicineKent State UniversityPrecision medicine, personalized medicine, cognitive computing, big data in healthcare, phamacogenomics
Medication Therapy ManagementcalvinbryantThe document discusses plans to implement a medication therapy management (MTM) program across Walgreens clinics. It outlines strategies for recruiting pharmacists, obtaining financing, marketing the program, focusing initial efforts on diabetes and hypertension, and addressing legal and ethical considerations to improve patient health outcomes through comprehensive medication reviews.
PharmacovigilanceRafi BhatPharmacovigilance is the science of monitoring the effects of pharmaceutical products after they have been licensed for use, especially in order to identify and evaluate previously unreported adverse reactions. It aims to improve patient care and safety, public health, benefit-risk assessment of medicines, and understanding of pharmacovigilance. Similarly, materiovigilance monitors medical devices and hemovigilance monitors the blood transfusion system to protect patient safety. Adverse events following immunization (AEFI) surveillance also monitors vaccine safety. Together these systems aim to enhance safety across all medical treatments.
MTM Presentationcken2009The document discusses medication therapy management (MTM) services provided by pharmacists. It notes that MTM aims to improve patient outcomes, promote safe medication use, and reduce costs. MTM services include comprehensive medication reviews, adherence support, and disease state management. Studies show MTM can identify and resolve medication-related problems, lower healthcare costs, and improve health outcomes for conditions like diabetes and asthma.
Randomized Clinical TrialsClinosolIndiaIn the pursuit of advancing medical knowledge and improving patient care, randomized clinical trials (RCTs) stand as the gold standard for rigorous and unbiased research. They are the backbone of evidence-based medicine, offering invaluable insights into the effectiveness and safety of medical interventions. Let's delve into the world of RCTs, exploring their significance, key principles, and their critical role in healthcare.
The Foundation of Evidence-Based Medicine
RCTs are the linchpin of evidence-based medicine, a paradigm that emphasizes clinical decisions based on empirical evidence and scientific inquiry. The fundamental premise of RCTs is to provide a structured and unbiased way to evaluate the efficacy and safety of medical treatments, interventions, or drugs.
Key Principles of Randomized Clinical Trials:
Randomization: Participants are randomly allocated into two or more groups, ensuring that each group is comparable at the outset. This minimizes the risk of bias in group assignment, enhancing the reliability of the results.
Control Group: RCTs typically include a control group that receives either a placebo or an existing standard treatment. The experimental group receives the new intervention under investigation.
Blinding: To minimize observer and participant bias, RCTs often employ blinding. Single-blind studies conceal information from either the participants or the investigators, while double-blind studies conceal information from both.
Outcomes and Endpoints: RCTs define specific outcomes or endpoints, such as disease progression, side effects, or mortality rates, to measure the intervention's impact.
Analysis of kinetic dataVineetha MenonThis document discusses population pharmacokinetic methods for analyzing drug absorption and disposition characteristics in populations. Traditional methods involve analyzing individual data first before pooling to determine population parameters, while newer methods analyze population data directly without evaluating individuals. Newer methods like mixed effect modeling separate inter-individual variability from other random errors and can derive population models from sparse individual data. Non-parametric methods do not assume a distribution for population parameters. Population pharmacokinetic methods are applied in drug development for dosage regimens and in clinical practice for individualized dosing.
Clinical pharmacy– a key roleNursing Hi NursingThis document provides an introduction to clinical pharmacy presented by Ian and Judith Coombes to students in Sri Lanka. In 3 sentences:
The presentation discusses the role of clinical pharmacy in improving patient care by identifying and resolving medication-related issues, outlines differences between healthcare systems in Australia and Sri Lanka, and emphasizes the need for pharmacists to adopt a patient-centered approach through effective communication and consultation to optimize drug therapy and prevent adverse events.
Pharmacoepidemiology and Pharmacoeconomics- Drug Use MeasurementsAnjaliBodapuntiDrug use can be measured in several ways, including monetary units, numbers of prescriptions, units of drug dispensed, defined daily doses, and prescribed daily doses. Medication adherence can also be measured through biological assays, pill counts, weight of topical medications, electronic monitoring, pharmacy records, patient interviews, patient estimates, and questionnaires. Each method has advantages and disadvantages related to accuracy, feasibility, and what information can be discerned about actual drug consumption and adherence patterns over time. Clinical judgement is required to establish appropriate measurement outcomes.
PharmacovigilanceVladimir PatrasThis document discusses pharmacovigilance and drug safety. It provides examples of drugs that have been withdrawn from the market in the US since 2000 due to safety issues like hepatotoxicity and cardiovascular toxicity. It also discusses key terms related to adverse drug reactions and how causality is assessed. Pharmacovigilance aims to identify safety issues with medicines through post-marketing surveillance.
Design of Dosage formDr. Ramesh BhandariThe document discusses various methods for designing dosage regimens, including individualized regimens based on pharmacokinetic measurements, population-based regimens, empirical regimens, and regimens based on partial pharmacokinetic data or nomograms. It also covers considerations for converting patients from intravenous to oral drug administration through sequential, switch, or step-down methods based on pharmacokinetic principles and calculations using steady-state drug concentrations and clearance. An example calculation is provided to determine an appropriate oral theophylline dosage based on intravenous aminophylline infusion rates.
Concept of risk in pharmacoepidemiology PresentationMdshams244This document discusses concepts of risk in pharmacoepidemiology. It defines risk as the likelihood of experiencing harm or loss, and risk factors as variables that increase the likelihood of developing a problem. Risk factors can be biological, environmental, or psychosocial. Risk is not certain - not everyone exposed will have an adverse outcome. Risk is also relative and depends on multiple interacting factors over time. In pharmacoepidemiology, risk refers to the probability of developing an outcome from drug exposure, which depends on factors like age, sex, and other medications. Risk is measured using metrics like attributable risk, relative risk, and odds ratio.
Drugs induced hematological disorders 2020Pravin PrasadThis document discusses drug-induced hematological disorders, focusing on drug-induced aplastic anemia, hemolytic anemia, and megaloblastic anemia. It defines each condition, describes their mechanisms, symptoms, risk factors, prevention, and treatment approaches. Drug-induced aplastic anemia is the most serious as it damages stem cells and reduces blood cell counts, potentially causing infections and bleeding. Treatment involves discontinuing the causative drug, immunosuppression, supportive care like transfusions, and sometimes stem cell transplantation. Drug-induced hemolytic anemia and megaloblastic anemia are also explained in terms of their causes, presentations, and management through removal of the offending drug and supplementation.
AN OVERVIEW AND IMPORTANCE OF PHARMACOVIGILANCERamakrishna KAn introduction to pharmacovigilance, basic types like active pharmacovigilance and passive pharmacovigilance, purpose, adverse event reporting, data processing, causality, assessement, signal detection, risk management plans and analysis
2 CONVERSION OF IV TO PO.pdfssuserbdaac4This document discusses converting patients from intravenous to oral medication dosing. It begins by outlining the benefits of oral dosing over intravenous, such as increased comfort and mobility for patients. There are three types of IV to oral conversions: sequential, switch, and step-down therapy. Selection of appropriate patients considers gastrointestinal function, improving clinical status, exclusion criteria like inability to swallow, and medication class pharmacokinetics. Successful conversion reduces costs and length of hospital stay while maintaining therapeutic drug levels.
Prescription event monitoring- rumana hameedRumana HameedThis document discusses Prescription Event Monitoring (PEM), a method of pharmacovigilance used in the UK. PEM involves collecting data on dispensed prescriptions from general practitioners and sending questionnaires to GPs to obtain additional information on patient outcomes. The method was developed in 1981 and allows monitoring of new drugs in real-world settings. It provides large sample sizes and can detect adverse events not found in clinical trials. However, PEM relies on doctor reporting and not all questionnaires are returned.
Pharmacokinetic and Pharmacodynamic ModelingJaspreet GurayaThe presentation gives you a bird eye's view regarding basics of PK-PD modeling, its applications, types, limitations and various softwares used for the same.
Health and Sustainable Development in MyanmarMYO AUNG Myanmarhttp://www.wpro.who.int/asia_pacific_observatory/hits/myanmar_pns1_en.pdf
What are the challenges facing Myanmar in progressing towards Universal Health Coverage?
https://www.irrawaddy.com/specials/challenges-impede-development-of-myanmars-public-health.html
Challenges Impede Development of Myanmar’s Public Health
https://europa.eu/capacity4dev/capacity-building-in-public-health-for-development/document/health-sector-reforms-myanmar-giving-more-space-public-health-interventions-ncds
Health Sector Reforms in Myanmar, giving more space for public health interventions for NCDs
Prescription Event Monitoring & Record Linkage SystemsSatish Veerla- Prescription-Event Monitoring (PEM) was established in 1981 to study the safety of new medications as used in general practice, as pre-marketing trials have limitations. PEM involves collecting data on all clinical events reported by patients after being prescribed a new drug.
- PEM provides clinically useful safety information as it establishes incidence densities of reported events from monitoring thousands of initial prescriptions of new drugs in real-world settings. This allows rare adverse drug reactions to be detected.
- Record linkage systems aim to link together records from different data sources that relate to the same individual or entity. This process involves standardizing, blocking, and matching records using identifiers and probabilistic methods. Record linkage improves data quality and coverage and is
Pharmacovigilance Anurag ChourasiaThis document discusses pharmacovigilance, which is the monitoring of adverse drug reactions. It aims to identify new safety issues with drugs, assess risks and benefits of medications, and optimize safe drug use. Pharmacovigilance is important because not all adverse reactions are found during clinical trials. The Pharmacovigilance Program of India was established in 2010 to monitor adverse drug reactions nationally. It operates through 250 Adverse Drug Reaction Monitoring Centers and has seen a rise in adverse reaction reporting over time. Actions taken from pharmacovigilance findings can include restricting drug use, adding warnings, and rarely recalling drugs from the market.
Markov modelNouran Hamza, MSc, PgDPHA Markov model is a mathematical modeling technique derived from matrix algebra that describes the transitions a cohort of patients make among a finite number of mutually exclusive and exhaustive health states over a series of short intervals or cycles. In a Markov model, patients are always in one of the defined health states and events are modeled as transitions between states. The contribution of utility to overall prognosis depends on the length of time spent in each health state. Transition probabilities are used to represent the likelihood of moving between states in each cycle. An example Markov model was provided to demonstrate these concepts.
EY-commercial-excellence-in-pharma-3-0HealthiExCommercial organizations in the pharmaceutical industry must enable multiple business models to adapt to shifting markets and evolving stakeholder needs. They must continuously understand and map changing value drivers for diverse stakeholders in order to provide dynamic value propositions through appropriate channels. This requires taking an agile, customer-centric approach organized around stakeholders, with business models that develop and adapt based on real-time learning. Pharma 3.0 emphasizes engaging directly with patients to improve health outcomes through collaborative, services-focused models.
Medication Adherence , setting up directions .. Ahmed Nouripresenting the terminology of adherence, statistics of non-adherence and its impact, why do patients have difficulty with treatment, how to measure and how to improve the adherence, in addition to the role of the pharmacist in improving adherence.
Role of a Pharmacologist By Dr.Harmanjit SinghGovt Medical College & Hospital, Sector-32A pharmacologist has several key roles:
1. Medical education - Teaching undergraduate and postgraduate students about rational drug use, effects, toxicity, and interactions.
2. Research - Conducting both basic and clinical research, ensuring adherence to guidelines for clinical trials and ethical reviews.
3. Regulatory affairs - Involved in essential drug lists, national drug policy, and regulatory bodies like drug authorities.
Pharmacy orietation-----(Pharmaceutics)Soft-LearnersPharmacy is the science and art of preparing and dispensing medications. Pharmacists play an important role in public health by providing drug information to patients and acting as experts on medications. The document outlines the diverse career opportunities available to pharmacists in fields like hospitals, clinics, community pharmacies, the pharmaceutical industry, government services, and more. Key roles of pharmacists include preparing medications, ensuring quality control, dispensing drugs, and counseling patients.
Analysis of kinetic dataVineetha MenonThis document discusses population pharmacokinetic methods for analyzing drug absorption and disposition characteristics in populations. Traditional methods involve analyzing individual data first before pooling to determine population parameters, while newer methods analyze population data directly without evaluating individuals. Newer methods like mixed effect modeling separate inter-individual variability from other random errors and can derive population models from sparse individual data. Non-parametric methods do not assume a distribution for population parameters. Population pharmacokinetic methods are applied in drug development for dosage regimens and in clinical practice for individualized dosing.
Clinical pharmacy– a key roleNursing Hi NursingThis document provides an introduction to clinical pharmacy presented by Ian and Judith Coombes to students in Sri Lanka. In 3 sentences:
The presentation discusses the role of clinical pharmacy in improving patient care by identifying and resolving medication-related issues, outlines differences between healthcare systems in Australia and Sri Lanka, and emphasizes the need for pharmacists to adopt a patient-centered approach through effective communication and consultation to optimize drug therapy and prevent adverse events.
Pharmacoepidemiology and Pharmacoeconomics- Drug Use MeasurementsAnjaliBodapuntiDrug use can be measured in several ways, including monetary units, numbers of prescriptions, units of drug dispensed, defined daily doses, and prescribed daily doses. Medication adherence can also be measured through biological assays, pill counts, weight of topical medications, electronic monitoring, pharmacy records, patient interviews, patient estimates, and questionnaires. Each method has advantages and disadvantages related to accuracy, feasibility, and what information can be discerned about actual drug consumption and adherence patterns over time. Clinical judgement is required to establish appropriate measurement outcomes.
PharmacovigilanceVladimir PatrasThis document discusses pharmacovigilance and drug safety. It provides examples of drugs that have been withdrawn from the market in the US since 2000 due to safety issues like hepatotoxicity and cardiovascular toxicity. It also discusses key terms related to adverse drug reactions and how causality is assessed. Pharmacovigilance aims to identify safety issues with medicines through post-marketing surveillance.
Design of Dosage formDr. Ramesh BhandariThe document discusses various methods for designing dosage regimens, including individualized regimens based on pharmacokinetic measurements, population-based regimens, empirical regimens, and regimens based on partial pharmacokinetic data or nomograms. It also covers considerations for converting patients from intravenous to oral drug administration through sequential, switch, or step-down methods based on pharmacokinetic principles and calculations using steady-state drug concentrations and clearance. An example calculation is provided to determine an appropriate oral theophylline dosage based on intravenous aminophylline infusion rates.
Concept of risk in pharmacoepidemiology PresentationMdshams244This document discusses concepts of risk in pharmacoepidemiology. It defines risk as the likelihood of experiencing harm or loss, and risk factors as variables that increase the likelihood of developing a problem. Risk factors can be biological, environmental, or psychosocial. Risk is not certain - not everyone exposed will have an adverse outcome. Risk is also relative and depends on multiple interacting factors over time. In pharmacoepidemiology, risk refers to the probability of developing an outcome from drug exposure, which depends on factors like age, sex, and other medications. Risk is measured using metrics like attributable risk, relative risk, and odds ratio.
Drugs induced hematological disorders 2020Pravin PrasadThis document discusses drug-induced hematological disorders, focusing on drug-induced aplastic anemia, hemolytic anemia, and megaloblastic anemia. It defines each condition, describes their mechanisms, symptoms, risk factors, prevention, and treatment approaches. Drug-induced aplastic anemia is the most serious as it damages stem cells and reduces blood cell counts, potentially causing infections and bleeding. Treatment involves discontinuing the causative drug, immunosuppression, supportive care like transfusions, and sometimes stem cell transplantation. Drug-induced hemolytic anemia and megaloblastic anemia are also explained in terms of their causes, presentations, and management through removal of the offending drug and supplementation.
AN OVERVIEW AND IMPORTANCE OF PHARMACOVIGILANCERamakrishna KAn introduction to pharmacovigilance, basic types like active pharmacovigilance and passive pharmacovigilance, purpose, adverse event reporting, data processing, causality, assessement, signal detection, risk management plans and analysis
2 CONVERSION OF IV TO PO.pdfssuserbdaac4This document discusses converting patients from intravenous to oral medication dosing. It begins by outlining the benefits of oral dosing over intravenous, such as increased comfort and mobility for patients. There are three types of IV to oral conversions: sequential, switch, and step-down therapy. Selection of appropriate patients considers gastrointestinal function, improving clinical status, exclusion criteria like inability to swallow, and medication class pharmacokinetics. Successful conversion reduces costs and length of hospital stay while maintaining therapeutic drug levels.
Prescription event monitoring- rumana hameedRumana HameedThis document discusses Prescription Event Monitoring (PEM), a method of pharmacovigilance used in the UK. PEM involves collecting data on dispensed prescriptions from general practitioners and sending questionnaires to GPs to obtain additional information on patient outcomes. The method was developed in 1981 and allows monitoring of new drugs in real-world settings. It provides large sample sizes and can detect adverse events not found in clinical trials. However, PEM relies on doctor reporting and not all questionnaires are returned.
Pharmacokinetic and Pharmacodynamic ModelingJaspreet GurayaThe presentation gives you a bird eye's view regarding basics of PK-PD modeling, its applications, types, limitations and various softwares used for the same.
Health and Sustainable Development in MyanmarMYO AUNG Myanmarhttp://www.wpro.who.int/asia_pacific_observatory/hits/myanmar_pns1_en.pdf
What are the challenges facing Myanmar in progressing towards Universal Health Coverage?
https://www.irrawaddy.com/specials/challenges-impede-development-of-myanmars-public-health.html
Challenges Impede Development of Myanmar’s Public Health
https://europa.eu/capacity4dev/capacity-building-in-public-health-for-development/document/health-sector-reforms-myanmar-giving-more-space-public-health-interventions-ncds
Health Sector Reforms in Myanmar, giving more space for public health interventions for NCDs
Prescription Event Monitoring & Record Linkage SystemsSatish Veerla- Prescription-Event Monitoring (PEM) was established in 1981 to study the safety of new medications as used in general practice, as pre-marketing trials have limitations. PEM involves collecting data on all clinical events reported by patients after being prescribed a new drug.
- PEM provides clinically useful safety information as it establishes incidence densities of reported events from monitoring thousands of initial prescriptions of new drugs in real-world settings. This allows rare adverse drug reactions to be detected.
- Record linkage systems aim to link together records from different data sources that relate to the same individual or entity. This process involves standardizing, blocking, and matching records using identifiers and probabilistic methods. Record linkage improves data quality and coverage and is
Pharmacovigilance Anurag ChourasiaThis document discusses pharmacovigilance, which is the monitoring of adverse drug reactions. It aims to identify new safety issues with drugs, assess risks and benefits of medications, and optimize safe drug use. Pharmacovigilance is important because not all adverse reactions are found during clinical trials. The Pharmacovigilance Program of India was established in 2010 to monitor adverse drug reactions nationally. It operates through 250 Adverse Drug Reaction Monitoring Centers and has seen a rise in adverse reaction reporting over time. Actions taken from pharmacovigilance findings can include restricting drug use, adding warnings, and rarely recalling drugs from the market.
Markov modelNouran Hamza, MSc, PgDPHA Markov model is a mathematical modeling technique derived from matrix algebra that describes the transitions a cohort of patients make among a finite number of mutually exclusive and exhaustive health states over a series of short intervals or cycles. In a Markov model, patients are always in one of the defined health states and events are modeled as transitions between states. The contribution of utility to overall prognosis depends on the length of time spent in each health state. Transition probabilities are used to represent the likelihood of moving between states in each cycle. An example Markov model was provided to demonstrate these concepts.
EY-commercial-excellence-in-pharma-3-0HealthiExCommercial organizations in the pharmaceutical industry must enable multiple business models to adapt to shifting markets and evolving stakeholder needs. They must continuously understand and map changing value drivers for diverse stakeholders in order to provide dynamic value propositions through appropriate channels. This requires taking an agile, customer-centric approach organized around stakeholders, with business models that develop and adapt based on real-time learning. Pharma 3.0 emphasizes engaging directly with patients to improve health outcomes through collaborative, services-focused models.
Medication Adherence , setting up directions .. Ahmed Nouripresenting the terminology of adherence, statistics of non-adherence and its impact, why do patients have difficulty with treatment, how to measure and how to improve the adherence, in addition to the role of the pharmacist in improving adherence.
Role of a Pharmacologist By Dr.Harmanjit SinghGovt Medical College & Hospital, Sector-32A pharmacologist has several key roles:
1. Medical education - Teaching undergraduate and postgraduate students about rational drug use, effects, toxicity, and interactions.
2. Research - Conducting both basic and clinical research, ensuring adherence to guidelines for clinical trials and ethical reviews.
3. Regulatory affairs - Involved in essential drug lists, national drug policy, and regulatory bodies like drug authorities.
Pharmacy orietation-----(Pharmaceutics)Soft-LearnersPharmacy is the science and art of preparing and dispensing medications. Pharmacists play an important role in public health by providing drug information to patients and acting as experts on medications. The document outlines the diverse career opportunities available to pharmacists in fields like hospitals, clinics, community pharmacies, the pharmaceutical industry, government services, and more. Key roles of pharmacists include preparing medications, ensuring quality control, dispensing drugs, and counseling patients.
2. Տիգրան Բ-ն Արտաշես Ա արքայի թոռն է, Տիրանի (Տիգրան Ա)
գահաժառանգ որդին: Մ. թ. ա. 113–112 թթ-ի հայ-
պարթևական պատերազմում պարտություն կրելով՝
անժառանգ Արտավազդ Ա-ն եղբորորդի Տիգրանին
ստիպված պատանդ է տվել պարթևներին: Հոր մահից հետո
Տիգրանը վերադարձել է հայրենիք և մ. թ. ա. 95 թ-ին
թագադրվել Աղձնիքի սրբավայրերից մեկում (հետագայում
այնտեղ կառուցել է Տիգրանակերտ մայրաքաղաքը): Իր
ազատության դիմաց նա պարթև Միհրդատ Բ
Արշակունուն (մ. թ. ա. 123–87 թթ.) զիջել է «Յոթանասուն
հովիտներ» կոչված տարածքը Մեծ Հայքի հարավ-
արևելքում:
3. Տիգրանն իր գահակալության երկրորդ տարում Մեծ Հայքին է
միացրել Ծոփքի թագավորությունը և դուրս եկել Եփրատի ափերը:
Մ. թ. ա. 94 թ-ին Արտաշատում կնքել է հայ-պոնտական դաշինքը:
Պոնտոսի թագավոր Միհրդատ VI Եվպատորն այդ առթիվ իր
դուստր Կլեոպատրային կնության է տվել Տիգրանին: Հավատարիմ
այդ դաշնագրին՝ մ. թ. ա. 93–91 թթ-ին Հայոց արքան վճռականորեն
պայքարել է Կապադովկիայում հռոմեական տիրապետության
հաստատման դեմ:
5. Տիգրան Բ-ն Տիգրանակերտի հիմնադրումով ստեղծել է կառավարման
ընդհանուր կենտրոն Հայկական տերության համար: Մ. թ. ա. 80–70-ական
թվականներին վարել է Պարթևստանի հետագա թուլացման և Արևելյան
Միջերկրայքում Հռոմի ազդեցության վերացման քաղաքականություն,
հակապարթևական դաշինքներ կնքել Պարսից ծոցի Խարակենե
արաբական պետության և Միջին Ասիայի քոչվորների՝ սակարաուկների
հետ, խրախուսել Միջերկրական ծովում ծովահենական շարժումը Հռոմի
դեմ, մ. թ. ա. 78 թ-ին գրավել է վերջինիս դաշնակից Կապադովկիան: Այդ
շրջանում Հայկական աշխարհակալ տերությունը տարածվում էր
Միջերկրական ծովից ու Եգիպտոսից մինչև Կասպից ծով և Կովկասյան
լեռներից մինչև Միջագետք:
6. Մ. թ. ա. 73–72 թթ-ին Տիգրան Բ-ն ճնշել է հայ ավագանու որոշ
հատվածի՝ Զարեհ արքայորդու գլխավորած
ապստամբությունը, մ. թ. ա. 73–69 թթ-ին Փյունիկիայում և
Հարավային Ասորիքում՝ Հռոմի Սելևկյան դրածոների, ինչպես
նաև նրանց դաշնակցած Նաբաթեայի (արաբական
պետություն) և Հուդայի (հրեական պետություն)
թագավորությունների ընդվզումները: Այդ պատճառով Տիգրան
Բ-ն չի կարողացել օգնել Միհրդատ VI-ին և չեզոք դիրք է
գրավել մ. թ. ա. 73–71 թթ-ի հռոմեա-պոնտական
պատերազմում: