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- 2. INTRODUCTION Tetracyclines are a class of antibiotic,which are chemical substances produced by a microorganism that are able to kill other microorganisms without being toxic to the person,animal or plant. Tetracyclines are derived directly from a bacterium known as Streptomyces coelicolor.
- 3. CLASSIFICATION OF TETRACYCLINE Tetracyclines (according to duration of action) Short acting (half life is 6- 8hrs) Tetracycline Oxytetracycline Intermediate- acting (half-life 12hrs) Demeclocycline Methacycline Long acting (half-life 16hrs) Doxycycline Minocycline
- 4. MECHANISM OF ACTION Tetracyclines are specific inhibitors of bacterial protien synthesis. They bind to the 30s ribosomal subunit and thereby prevent the binding of aminoacyl tRNA to the mRNA ribosome complex. Tetracyclines also inhibit protein synthesis in the host,but are less likely to reach the concentration required because eukaryotic cells do not have a tetracycline uptake mechanism.
- 5. SPECTRUM OF ACTIVITY Tetracyclines are broad spectrum antibiotics,active against Gram positive and Gram negative bacteria.
- 7. ADMINISTRATION Oral capsules is the dosage form in which tetracyclines are most commonly administered. The capsule should be taken 1/2hr before or 2hr after food. Not recommended for i.m. route of administration.
- 8. USES OF TETRACYCLINE Tetracycline is used to treat wide variety of infections, including acne. It is an antibiotic that works by stopping the growth of bacteria. Venerel disease Atypical pneumonia Cholera Relapsing fever Rickettsial infections,plague
- 9. DRUG INTERACTION Tetracycline may interact with other medicine. Effects of one or both of drugs may change or rick of side effect may be greater. Calcium supplements Mineral supplements Multivitamin Cholesterol lowering drugs Penicillin compounds