Multiple system atrophy (MSA) is a rare, rapidly progressive neurodegenerative disease characterized by autonomic dysfunction, parkinsonism, and cerebellar ataxia. MSA is pathologically classified into MSA-P and MSA-C subtypes based on predominant symptoms. Diagnostic criteria require autonomic dysfunction with either parkinsonism or cerebellar ataxia, along with supportive MRI or neuroimaging findings. Compared to Parkinson's disease, MSA has a poorer prognosis with average survival of 7-9 years after onset.
Multiple system atrophy (MSA) is a rare, rapidly progressive neurodegenerative disease characterized by autonomic dysfunction, parkinsonism, and cerebellar ataxia. MSA is pathologically classified into MSA-P and MSA-C subtypes based on predominant symptoms. Diagnostic criteria require autonomic dysfunction with either parkinsonism or cerebellar ataxia, along with supportive MRI or neuroimaging findings. Compared to Parkinson's disease, MSA has a poorer prognosis with average survival of 7-9 years after onset.