Immune Thrombocytopenia (ITP) is an autoimmune disorder characterized by low platelet count due to increased platelet destruction and impaired production. The bone marrow findings in ITP show increased immature megakaryocytes with scant cytoplasm and absent lobulation in the nucleus. Dysplastic megakaryocytes with separated nuclei and micromegakaryocytes are also seen. Megakaryocytes in ITP frequently show emperipolesis of lymphocytes or lymphocytes and nucleated red blood cells within the cytoplasm. These bone marrow findings are sensitive and specific for diagnosing ITP.
Immune Thrombocytopenia (ITP) is an autoimmune disorder characterized by low platelet count due to increased platelet destruction and impaired production. The bone marrow findings in ITP show increased immature megakaryocytes with scant cytoplasm and absent lobulation in the nucleus. Dysplastic megakaryocytes with separated nuclei and micromegakaryocytes are also seen. Megakaryocytes in ITP frequently show emperipolesis of lymphocytes or lymphocytes and nucleated red blood cells within the cytoplasm. These bone marrow findings are sensitive and specific for diagnosing ITP.
