O documento resume a hist¨®ria da Turma da M?nica Jovem 93. Nele, Cebola est¨¢ muito triste por causa do t¨¦rmino do namoro com M?nica. Ele chega a dormir mal e n?o se alimentar bem. Apesar de ter namorado brevemente Nadine, ele continua apaixonado por M?nica. Um vil?o altera a realidade para que ningu¨¦m mais se lembre de M?nica, exceto Cebola. No final, Cebola se sacrifica para trazer M?nica de volta, desaparecendo
Ocular drug delivery systems aim to overcome barriers to drug absorption by the eye and provide sustained drug release. They include novel formulations like liposomes, niosomes, microparticles and nanoparticles that can target ocular tissues. Controlled release systems like implants, contact lenses and Ocuserts maintain drug levels for extended periods. Alternative routes like intravitreal injections provide direct access to intraocular structures. Together, these approaches enhance ocular bioavailability and drug efficacy while reducing administration frequency.
This document provides an overview of 3D printing in pharmaceutical applications. It begins with definitions of 3D printing and how the process works by layering materials. Applications discussed include personalized drug dosing based on patient characteristics, complex drug release profiles using multi-layer pills, and potential future applications like printing living tissues. Specific innovations like Aprecia's ZipDose technology are examined. Both advantages like customization and disadvantages like intellectual property issues are addressed. Risks involving product liability, cybersecurity, and safety of 3D printed drugs are also summarized. The document concludes 3D printing could revolutionize drug development through personalized and flexible delivery methods.