Huyu 7191
- 1. Tr??ng cao ??ng kinh t? c?ng ngh? TP.HCM khoa : c?ng ngh? sinh h?c l?p: C4SH3 B¨¤i c¨¢o c¨¢o T? B?O G?C Th¨¤nh vi¨ºn: ?Ph?m L¨º Huy ?H? Minh Ho¨¤ng ?Nguy?n Qu?c Hi?u ?L?i Ng?c Hi?n ??¨¤o Th¨¤nh Tr?c ??? H?ng S?n
- 2. T? b¨¤o g?c M?t s? kh¨¢i ni?m T? b¨¤o g?c x?p lo?i t? b¨¤o g?c Ngu?n l?y t? b¨¤o g?c
- 3. M?t s? kh¨¢i ni?m
- 4. Bi?t h¨®a (differentiation) ? L¨¤ qu¨¢ tr¨¬nh c¨¢c t? b¨¤o mang m?t ??c t¨ªnh ri¨ºng bi?t v¨¤ tr? th¨¤nh ¡°???c ??nh h¨¬nh¡± d??i g¨®c ?? ph?i thai h?c.
- 5. Chuy?n bi?t h¨®a (transdifferentiation): ? L¨¤ kh? n?ng m?t t? b¨¤o g?c, ph?n n¨¤o ?? ¡°???c ??nh h¨¬nh¡±, c¨® th? bi?t h¨®a th¨¤nh c¨¢c lo?i t? b¨¤o kh¨¢c v?i lo?i m¨¤ n¨® ¡°???c ??nh h¨¬nh¡± V¨ª d? :t? b¨¤o g?c t?o m¨¢u c¨® th? bi?t h¨®a th¨¤nh c¨¢c t? b¨¤o th?n kinh ho?c c¨¢c t? b¨¤o c?.
- 6. Gi?i bi?t h¨®a (dedifferentiation) ? L¨¤ qu¨¢ tr¨¬nh trong ?¨® ??c t¨ªnh ¡°???c ??nh h¨¬nh¡± c?a m?t t? b¨¤o b? ??o ng??c. T?c l¨¤ t? m?t t? b¨¤o ?? bi?t h¨®a tr? th¨¤nh t? b¨¤o ¨ªt bi?t h¨®a h?n ? Trong tr??ng h?p n¨¤y c¨¢c t? b¨¤o g?c t?o m¨¢u ?? quay tr? l?i m?t giai ?o?n ¡°tr? h?n¡± ?? c¨® th? kh?ng bi?t h¨®a th¨¤nh c¨¢c t? b¨¤o m¨¢u n?a m¨¤ bi?t h¨®a th¨¤nh c¨¢c t? b¨¤o kh¨¢c (th?n kinh, c? ¡).
- 7. T? b¨¤o g?c l¨¤ g¨¬? T? b¨¤o g?c ch?a bi?t h¨®a c¨® th? t? t¨¢i t?o ph?n chia nhi?u l?n Trong nh?ng ?i?u ki?n sinh l?/th?c nghi?m nh?t ??nh, t? b¨¤o g?c c¨® th? c?m ?ng bi?t h¨®a th¨¤nh c¨¢c t? b¨¤o c¨® ch?c n?ng chuy¨ºn bi?t nh? t? b¨¤o c? tim, t? b¨¤o tuy?n t?y, t? b¨¤o b¨¤o da, t? b¨¤o m¨¢u, t? b¨¤o th?n kinh¡
- 8. T? b¨¤o g?c to¨¤n n?ng X?p lo?i theo ??c T? b¨¤o g?c v?n n?ng t¨ªnh hay m?c ?? bi?t ho¨¢ T? b¨¤o g?c ??n n?ng T? b¨¤o g?c ?a n?ng Ph?n lo?i T? b¨¤o g?c ph?i X?p lo?i theo ngu?n g?c ph?n l?p T? b¨¤o g?c thai T? b¨¤o g?c tr??ng th¨¤nh
- 9. T? b¨¤o g?c to¨¤n n?ng hay t? b¨¤o g?c th?y t? (totipotent stem cells) c¨® kh? n?ng ph¨¢t tri?n T? b¨¤o g?c to¨¤n c¨® kh? th¨¤nh thai nhi n?ng n?ng bi?t h¨®a th¨¤nh t?t c? c¨¢c lo?i t? h?p t? (giai ?o?n 2 - 4 t? b¨¤o c? b¨¤o) th? t? m?t t? b¨¤o ban ??u
- 10. T? b¨¤o g?c v?n n?ng (pluripotent stem cells) ? kh? n?ng bi?t h¨®a th¨¤nh t?t c? c¨¢c t? b¨¤o c?a c? th? c¨® ngu?n g?c t? ba l¨¢ m?m ph?i: l¨¢ trong, l¨¢ gi?a v¨¤ l¨¢ ngo¨¤i. Ba l¨¢ m?m ph?i n¨¤y l¨¤ ngu?n g?c c?a t?t c? c¨¢c lo?i t? b¨¤o chuy¨ºn bi?t kh¨¢c nhau c?a c? th? ? ch? c¨® th? t?o n¨ºn ???c c¨¢c t? b¨¤o, m? nh?t ??nh
- 11. T? b¨¤o g?c ?a n?ng (multipotent stem cells): ? t? b¨¤o c¨® kh? n?ng bi?t h¨®a th¨¤nh nhi?u lo?i t? b¨¤o ,C¨¢c t? b¨¤o ???c t?o th¨¤nh n?m trong m?t h? t? b¨¤o c¨® li¨ºn quan m?t thi?t
- 12. T? b¨¤o g?c ??n n?ng (mono/unipotential progenitor cells) ? T? b¨¤o g?c ??n n?ng, c¨°n g?i l¨¤ t? b¨¤o ??nh h??ng ??n d¨°ng hay t? b¨¤o ??u d¨°ng (progenitor cells), l¨¤ nh?ng t? b¨¤o g?c ch? c¨® kh? n?ng bi?t h¨®a theo m?t d¨°ng. ? th? bi?t h¨®a th¨¤nh ch? m?t d¨°ng t? b¨¤o ? Kh? n?ng bi?t h¨®a theo d¨°ng n¨¤y cho ph¨¦p duy tr¨¬ tr?ng th¨¢i s?n s¨¤ng t? t¨¢i t?o m?, thay th? c¨¢c t? b¨¤o m? ch?t v¨¬ gi¨¤ c?i b?ng c¨¢c t? b¨¤o m? m?i.
- 13. T? b¨¤o g?c ph?i (Embryonic stem cells-ESCs) v¨¤ t? b¨¤o m?m ph?i (Embryonic germ cells) ?T? b¨¤o g?c ph?i: ? l¨¤ c¨¢c t? b¨¤o g?c v?n n?ng ???c l?y t? ph?i giai ?o?n s?m (4-7 ng¨¤y tu?i). ?T? b¨¤o m?m ph?i : ?l¨¤ c¨¢c t? b¨¤o m?m nguy¨ºn th?y c¨® t¨ªnh v?n n?ng ??¨® l¨¤ c¨¢c t? b¨¤o s? h¨¬nh th¨¤nh n¨ºn giao t? (tr?ng v¨¤ tinh tr¨´ng) ? ng??i tr??ng th¨¤nh ?C¨¢c t? b¨¤o m?m nguy¨ºn th?y n¨¤y ???c ph?n l?p t? ph?i 5- 9 tu?n tu?i ho?c t? thai nhi. So v?i t? b¨¤o g?c ph?i, c¨¢c t? b¨¤o m?m ph?i kh¨® duy tr¨¬ d¨¤i h?n h?n trong nu?i c?y nh?n t?o do ch¨²ng ? giai ?o?n bi?t h¨®a cao h?n.
- 14. T? b¨¤o g?c thai (Foetal stem cells) ? L¨¤ c¨¢c t? b¨¤o v?n n?ng ho?c ?a n?ng ???c ph?n l?p t? t? ch?c thai sau n?o ph¨¢ thai ho?c t? m¨¢u cu?ng r?n sau khi sinh. Nhi?u ng??i cho r?ng, t? b¨¤o g?c thai thu?c lo?i t? b¨¤o g?c tr??ng th¨¤nh ? giai ?o?n bi?t h¨®a th?p.
- 15. b¨¤o g?c tr??ng th¨¤nh (Adult stem cells/Somatic stem cells) ? t? b¨¤o g?c th?n ? L¨¤ c¨¢c t? b¨¤o ch?a bi?t h¨®a ???c t¨¬m th?y v?i m?t s? l??ng ¨ªt trong c¨¢c m? c?a ng??i tr??ng th¨¤nh ? B¨¬nh th??ng, c¨¢c t? b¨¤o g?c tr??ng th¨¤nh ???c cho l¨¤ c¨® t¨ªnh ?a n?ng, ? Tuy nhi¨ºn, c¨¢c b?ng ch?ng g?n ??y cho th?y m?t s? lo?i t? b¨¤o g?c tr??ng th¨¤nh c¨°n c¨® th? c¨® t¨ªnh v?n n?ng
- 16. Ngu?n l?y t? b¨¤o g?c M¨¤ng trong d? con Kh?i t? b¨¤o b¨ºn trong L¨¢ m?m ph?i Khoang ph?i
- 17. Ngu?n l?y t? b¨¤o g?c ph?i ? T? b¨¤o g?c ph?i ???c l?y t? kh?i t? b¨¤o b¨ºn trong (inner cell mass) c?a ph?i t¨²i (blastocyst) ph¨¢t tri?n t?: ?C¨¢c ph?i t?o n¨ºn b?ng k? thu?t th? tinh trong ?ng nghi?m. ?C¨¢c ph?i nh?n b?n (cloned embryo) t?o n¨ºn b?ng t¨¢ch blastosomer trong giai ?o?n ph?i 2- 4 t? b¨¤o, ho?c b?ng ph?n chia blastocyst. ?C¨¢c ph?i nh?n b?n v? t¨ªnh t?o n¨ºn b?ng k? thu?t chuy?n nh?n t? b¨¤o th?n.
- 18. Ngu?n l?y t? b¨¤o m?m ph?i v¨¤ t? b¨¤o g?c thai ? Ngu?n l?y t? b¨¤o m?m ph?i v¨¤ t? b¨¤o g?c thai l¨¤ thai ??ng v?t ho?c thai thai nhi n?o b?. V?i thai ng??i n?o b?, th??ng ch? l?y ? thai nhi d??i 6 tu?n tu?i (thai s?m, m?c ?? bi?t h¨®a ch?a cao). T? ch?c m?m sinh d?c thai l¨¤ n?i l?y t? b¨¤o m?m ph?i, c¨¢c t? ch?c kh¨¢c c?a thai (n?o, gan) l¨¤ n?i l?y t? b¨¤o g?c thai.
- 19. Ngu?n l?y t? b¨¤o g?c tr??ng th¨¤nh ? Th??ng l?y t? c¨¢c t? ch?c tr??ng th¨¤nh nh?: m¨¢u cu?ng r?n, trung m? cu?ng r?n, t?y x??ng, m¨¢u ngo?i vi, nang l?ng, t? ch?c n?o
- 21. T? b¨¤o g?c ph?i T? b¨¤o g?c tr??ng th¨¤nh C¨® ? ph?i t¨²i (blastocyst) v?i s? l??ng l?n C¨® ? c¨¢c m? tr??ng th¨¤nh, s? l??ng ¨ªt. D? nu?i c?y nh?n t?o Kh¨® nu?i c?y nh?n t?o h?n C¨® t¨ªnh v?n n?ng cao h?n, d? t?ng sinh tr¨ºn V? c? b?n c¨® t¨ªnh ?a n?ng, c¨® th? c¨® t¨ªnh nu?i c?y in vi tro, cho ph¨¦p t?o ra l??ng l?n. v?n n?ng Nguy c? t?o c¨¢c kh?i u teratoma cao ?t nguy c? t?o c¨¢c kh?i u teratoma G?n nh? b?t t? Kh?ng b?t t?, s? l?n ph?n chia b? gi?i h?n Do l?y t? m?t c? th? kh¨¢c n¨ºn t? b¨¤o g?c - Kh?ng b?t ??ng mi?n d?ch, kh?ng ph?i ¡°l?¡± v?i c? th? nh?n v¨¬ th? c¨® nguy c? g?y th?i gh¨¦p n?u l¨¤ gh¨¦p t? th?n. g?y n¨ºn ph?n ?ng th?i gh¨¦p. - N?u gh¨¦p cho m?t ng??i kh¨¢c th¨¬ v?n b?t ??ng g?y ph?n ?ng th?i gh¨¦p. Kh?ng d¨´ng ???c cho gh¨¦p t? th?n, tr? C¨¢c t? b¨¤o g?c c?a b?n th?n l¨¤ ngu?n tr??ng h?p t? b¨¤o g?c t?o ra b?ng k? t? b¨¤o t?t nh?t cho gh¨¦p. thu?t nh?n b?n t?o ph?i v? t¨ªnh.
- 22. I love you English???I?love?you? Afrikaans???Ek?het?jou?lief? Albanian???Te?dua? Arabic???Ana?behibak?(to?male)? Arabic???Ana?behibek?(to?female)? Armenian???Yes?kez?sirumen? Bambara???M'bi?fe? Bangla???Aamee?tuma?ke?bhalo?aashi? Belarusian???Ya?tabe?kahayu? Bisaya???Nahigugma?ako?kanimo? Bulgarian???Obicham?te? Cambodian???Soro?lahn?nhee?ah? Cantonese?Chinese???Ngo?oiy?ney?a?