This document discusses various screening models used to test potential antidepressant drugs. It begins by defining depression and its symptoms. It then discusses several theories of depression's mechanisms. Various in vivo animal models are described for screening antidepressants, including the forced swim test, tail suspension test, and learned helplessness test. The document provides details on procedures and evaluations for these and other models, such as amphetamine potentiation and NE toxicity tests in mice. The goal of screening models is to see how potential drugs correlate with known antidepressants' clinical efficacy and pharmacological effects.
This document discusses various screening models used to test potential antidepressant drugs. It begins by defining depression and its symptoms. It then discusses several theories of depression's mechanisms. Various in vivo animal models are described for screening antidepressants, including the forced swim test, tail suspension test, and learned helplessness test. The document provides details on procedures and evaluations for these and other models, such as amphetamine potentiation and NE toxicity tests in mice. The goal of screening models is to see how potential drugs correlate with known antidepressants' clinical efficacy and pharmacological effects.